CentiMorgan

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FTDNA's Family Finder and 23andMe's Relative Finder and Family Inheritance: Advanced use this term to measure the matching DNA segments.

In genetics, a centiMorgan (cM) or map unit (m.u.) is a unit of recombinant frequency which is used to measure genetic distance. It is often used to imply distance along a chromosome, and takes into account how often recombination occurs in a region. A region with few cMs undergoes relatively less recombination. The number of base pairs to which it corresponds varies widely across the genome (different regions of a chromosome have different propensities towards crossover). One centiMorgan corresponds to about 1 million base pairs in humans on average. The centiMorgan is equal to a 1% chance that a marker at one genetic locus on a chromosome will be separated from a marker at a second locus due to crossing over in a single generation.

The centiMorgan was named in honor of geneticist Thomas Hunt Morgan by his student Alfred Henry Sturtevant. Note that the parent unit of the centiMorgan, the Morgan, is rarely used today.

23andMe and Family Tree DNA both use HapMap to infer their centiMorgans.

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centiMorgans vs megabases

CentiMorgans are interpolated numbers that take into consideration each area of a chromosome and its propensity to recombine. This means if two cousins share 40 cM on chromosome 1, and two different cousins share 40 cM on chromosome 5, they both can be predicted to share a certain degree of relationship statistically. Megabases vary slightly in different locations so that in the same scenario, if both sets shared 40 Mb pairs, it would be more difficult to ensure they are of a similar degree of relation without further accounting for location, chromosome and other factors.[1]

As the cM is an empirical measure, based on recombination events in a particular dataset of parent/child trios, it can vary somewhat from study to study. This set of maps for each chromosome shows that the general shape of the centiMorgan vs megabase curve is similar for two datasets, but the absolute values are not quite the same:

http://web.archive.org/web/20070113005025/http://compgen.rutgers.edu/maps/compare.pdf

Ann Turner provides a useful explanation: "I think of the cM as being a unit of 'effective' distance. As an analogy, a mile is a fixed quantity (5280 feet), and so are megabases. But the probability that a person can walk a mile in 20 minutes is more fluid. If the terrain is very rough, the "effective" distance of a literal mile might be more like two miles if you're trying to arrive at a certain time. We're more interested in the probability that a segment will be passed on intact than the size of the segment in Mb".[2]

Converting centiMorgans into percentages

In order to get an approximate percentage of shared DNA from a Family Tree DNA Family Finder test, take all of the segments above 5 cM, add them together and then divide by 68.

The way the calculation works is that your total genome in cMs with the Family Finder test is 6770 cM. A half-identical match (such as a parent/child) is 3385 cM. This number has to be doubled to represent both the maternal and paternal sides giving a total of 6770 cM. Matt Dexter explains: "The reason the number is not 6770 or 6800, but rather 68, is that it saves an additional step doing the math to convert an answer to percent. For example, 3385 / 6770 = .5 then as a second step, .5 times 100 = 50%. Using 68 to start with saves the added math step. So (3385 / 6800) * 100 is the same thing as 3385 / 68, which results in = 50%."[3]

References

  1. Matt Dexter. Megabases versus centiMorgans Message posted on the ISOGG Group Administrators' mailing list, 21 June 2014.
  2. Ann Turner. centiMorgans vs megabases. Message posted on the ISOGG Group Administrators' mailing list, 22 June 2014.
  3. Matt Dexter. Message posted on the ISOGG DNA Newbie list in a thread entitled "DNA Conference Thank You", 13 November 2013.

See also

External links


GNU head This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CentiMorgan".