Short tandem repeat
A short tandem repeat (STR) in DNA occurs when a pattern of two or more nucleotides are repeated and the repeated sequences are directly adjacent to each other. An STR is also known as a microsatellite. The pattern can range in length from 2 to 16 base pairs (bp) and is typically in the non-coding intron region. A short tandem repeat polymorphism (STRP) occurs when homologous STR loci differ in the number of repeats between individuals. By identifying repeats of a specific sequence at specific locations in the genome, it is possible to create a genetic profile of an individual. Autosomal STR analysis has become the prevalent analysis method for determining genetic profiles in forensic cases. Y-chromosome STRs (Y-STRs) on the Y chromosome) are used in genealogical DNA testing in surname DNA projects.
- Christian M. Ruitberg, Dennis J. Reeder and John M. Butler. STRBase: a short tandem repeat DNA database for the human identity testing community. Nucelic Acids Research, 2001, Vol. 29, No. 1, pp320–322.
- John M. Butler. Forensic DNA Typing: Biology, Technology, and Genetics of STR Markers. Second Edition, Academic Press, 2005.
- National Institute of Standards and Technology (NIST) standard reference database
- National Institute of Standards and Technology (NIST fact sheets)
- Michael L. Hébert's Y-DNA Testing Company STR Marker Comparison Chart
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