SNP testing

From ISOGG Wiki
Jump to: navigation, search

SNP testing is required to confirm haplogroup assignments, to learn more about your deep ancestry and to rule out false positive matches. Y-SNP chip tests are available from the Genographic Project and BritainsDNA. More comprehensive sequencing tests using next generation sequencing technology are available from Full Genomes Corporation and Family Tree DNA. Single SNPs and SNP panels can be ordered from Family Tree DNA and YSEQ.

For advice on Single-nucleotide polymorphism aka SNP testing, please consult the project administrator of the relevant Y-DNA haplogroup project.

Single SNPs

There are currently two companies that offer single SNPs.

Family Tree DNA offer a range of single SNPs at US $39 per SNP.[1] SNPs can only be ordered by existing FTDNA customers who have already taken a Y chromosome DNA test with the company. In October 2013 over 3500 individual SNPs were available to order from FTDNA. The placement on the phylogenetic tree is unknown for most of them. SNPs with a known placement are highlighted in the customer's personal results page under the Y-DNA Haplotree & SNPs section. Customers can also request that new SNPs are added to the catalogue.

YSEQ is a new company established by Thomas and Astrid Krahn in November 2013. YSEQ offer a potentially unlimited menu of single SNPs to order. For further details of this company see the blog post by Debbie Kennett entitled YSEQ a new company offering single SNPs.

Checking for similarity mainly to X and primer development using +/-500bp: up to 90% is good, up to 95% possible - http://genome.ucsc.edu/cgi-bin/hgBlat?command=start

SNP panels

SNP panels (formerly known as deep clade tests) are available from YSEQ and Family Tree DNA. Many of these panels are still under development. It is best to check with the volunteer administrators of the relevant haplogroup project before ordering any such test.

The old deep clade tests from Family Tree were withdrawn from sale in January 2013.[2]

Next generation sequencing

Next generation sequencing tests are the most advanced SNP tests available on the market and can be used for SNP discovery. There are currently two products available for the genetic genealogy market: the Big Y test from Family Tree DNA and the Y Elite 2.0 test from Full Genomes Corporation.

Further reading

FTDNA Learning Center articles

Blog posts

Videos

"Y-SNPs - key to the future" - a presentation by Robert Casey explaining the importance of SNP testing:

Footnotes

  1. The price was raised from $29 per SNP to $39 per SNP in January 2013.
  2. "Exciting new developments at FTDNA". E-mail from Family Tree DNA to Y-DNA haplogroup project administrators, 25 January 2013.

See also